Produced as a byproduct of muscle metabolism, creatinine is formed from the breakdown of creatine, a compound found in muscles. What is Creatinine?Ĭreatinine is a critical biomarker used to assess kidney function, providing essential information about the overall health of these organs. Regular BUN testing can aid in the early detection of kidney dysfunction, allowing for timely interventions and improved patient outcomes. It's essential to interpret BUN levels in conjunction with other laboratory tests, such as the creatinine test, for a more accurate assessment of kidney health. Elevated BUN levels can be associated with dehydration, high protein intake, or kidney disease, while lower levels may be linked to liver disease or malnutrition. The kidneys, responsible for filtering waste and maintaining overall fluid balance, process and eliminate urea nitrogen through urine.Īn abnormal BUN level may indicate impaired kidney function or other underlying health issues. Urea nitrogen is a waste product generated from the natural breakdown of proteins in the body. What is Blood Urea Nitrogen (BUN)?īlood Urea Nitrogen ( BUN) is a crucial component of kidney function evaluation, as it measures urea nitrogen levels in the blood. In doing so, patients can achieve better health outcomes and quality of life. Incorporating conventional therapies with complementary methods like dietary modifications, stress reduction, and lifestyle changes, functional medicine offers a comprehensive and holistic strategy to address both the symptoms and underlying factors contributing to kidney disease. Healthcare professionals can assess kidney function and tailor treatments to the individual's needs by measuring the levels of these waste products in the blood. Early detection and intervention are crucial in managing CKD, and Blood Urea Nitrogen (BUN) and creatinine tests play a critical role in functional medicine approaches to kidney health. Please direct any questions regarding coding to the payer being billed.An estimated 10% of the global population is affected by chronic kidney disease (CKD), a progressive condition that can lead to kidney failure if left untreated. CPT coding is the sole responsibility of the billing party. The CPT codes provided are based on AMA guidelines and are for informational purposes only. In most cases of chronic renal disease, the ratio remains relatively normal. When there is decreased formation of urea, as seen in liver disease, there is a decrease in the BUN/Creatinine ratio. Increased urea formation also results in an increase in the ratio, e.g. congestive heart failure or recent onset of urinary tract obstruction, will result in an increase in BUN/Creatinine ratio. Please Note: If results for BUN and Creatinine are both within the normal reference range, the BUN/Creatinine ratio will not be reported (not applicable).Ĭlinical Significance: The BUN/Creatinine ratio is useful in the differential diagnosis of acute or chronic renal disease. To calculate the new eGFR from a previous Creatinine or Cystatin C result, go to. The eGFR is based on the CKD-EPI 2021 equation. Methodology: Photometric Assay, Calculation Transport: Store serum at 2☌ to 8☌ after collection and ship the same day per packaging instructions included with the provided shipping box.Ĭauses for Rejection: Specimens other than serum improper labeling samples not stored properly samples older than stability limits Gently invert tube 5 times immediately after draw.Collect and label sample according to standard protocols.Includes: Blood Urea Nitrogen (BUN), Serum Creatinine, BUN/Creatinine Ratio, Estimated Glomerular Filtration Rate (eGFR)Ĭontainer: Gel-barrier tube (SST, Tiger Top)
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